Rest It is important you take plenty of rest for the first two to three weeks after your glandular fever symptoms begin. However, complete bed rest is no longer recommended, as it can make the symptoms of fatigue last longer. You should gradually increase your activities as your energy levels return, but it is important to avoid activities you cannot manage comfortably. You can return to work, college or school as soon as you feel well enough. There is little risk of spreading the infection to others as long as you follow commonsense precautions, such as not kissing other people or sharing utensils. For the first month after your symptoms begin, avoid contact sports or activities that put you at risk of falling. This is because if you have a swollen spleen, it is more vulnerable to damage and a sudden knock could cause it to rupture.