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Cannot get rid of URLs

N/A

Cannot get rid of URLs

I have posted re. this issue before, but have yet to resolve the issue.
There is a website URL lodged at:

C:\WINDOWS\system32\shdoclc.dll/offcancl.htm#http://portal.plus.net/index_portal.html

which pops up as an autocomplete. I have tried Ad-Aware, Spybot, full AV sweep, but cannot remove it.
Can anyone suggest a safe way that I can manually delete this URL?
Thanks.