I've just installed Skype on my home computer and works laptop. On my laptop it works fine when I'm on a wired or wireless connection away from home, i.e. work, hotel etc.
But on my home Plusnet Premier connection I get radom brief (couple of seconds) interuptions on both my desktop and laptop.
I have a D-link DSL-300T modem connected to a Belkin high speed wireless router (via the wlan port), desktop is connected to belkin router via ethernet connection other computers by wireless connection.
Now I've seen (heard) the Skype problems I've also note brief interuptions on downloads and opening up pages occasionally, other than that speed is very good.